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Regorafenib Monohydrate

Product ID R1626
Cas No. 1019206-88-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $41.00 In stock
5 mg $54.50 In stock
25 mg $95.50 In stock
100 mg $252.10 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Regorafenib is an orally bioavailable multikinase inhibitor. This compound is clinically used in the treatment of metastatic colorectal cancer and non-responsive gastrointestinal stromal tumors. Regorafenib displays anticancer chemotherapeutic and anti-angiogenic properties, selective primarily for VEGFR2 but also displaying inhibitory activity against TIE2, VEGFR1/3, PDGFR-β, FGFR1, c-Kit, RET, and B-Raf.

Product Info

Cas No.

1019206-88-2

Purity

≥99%

Formula

C21H15ClF4N4O3 • H2O

Formula Wt.

500.83

IUPAC Name

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3- fluorophenoxy]-N-methylpyridine-2-carboxamide;hydrate

Synonym

BAY73-4506

Solubility

insoluble in water between pH1 and 13, slightly soluble in methanol; ethanol and sparingly soluble in acetone

Appearance

off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R1626 MSDS PDF

Info Sheet

R1626 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Abou-Elkacem L, Arns S, Brix G, et al. Regorafenib inhibits growth, angiogenesis, and metastasis in a highly aggressive, orthotopic colon cancer model. Mol Cancer Ther. 2013 Jul;12(7):1322-31. PMID: 23619301.

Wilhelm SM, Dumas J, Adnane L, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer. 2011 Jul 1;129(1):245-55. PMID: 21170960.

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