Dexamethasone

Name: Dexamethasone
SKU: D1693
Availability: InStock

Product ID D1693

Cas No. 50-02-2

Purity ≥97%

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Product Info
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Description

Dexamethasone is a glucocorticoid that exhibits anti-inflammatory and immunosuppressive activities with minimal mineralocorticoid effect. Under inflammatory conditions, dexamethasone decreases secretion of TNF, IL-6, and IL-1β, inhibiting migration and maturation of macrophages. Dexamethasone may also display anti-asthma benefit as well, through the upregulation of PTEN expression. Additionally, dexamethasone is often used in combination with other chemotherapies in the treatment of multiple myeloma.

Product Info

Cas No.	50-02-2
Purity	≥97%
Formula	C₂₂H₂₉FO₅
Formula Wt.	392.46
Chemical Name	(11β,16α)-9-Fluoro-11,17,21-trihydro-16-methyl- pregna-1,4-diene-3,20-dione
IUPAC Name	(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11, 17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-3-one
Synonym	Decadron, Maxidex
Melting Point	223-233°C
Solubility	Soluble in DMF (25 mg/mL) and DMSO (25 mg/mL). Sparingly soluble in ethanol. Insoluble in water.
Appearance	White Crystalline Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	D1693 MSDS PDF
Info Sheet	D1693 Info Sheet PDF

References

Bartneck M, Peters FM, Warzecha KT, et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Mar 7. [Epub ahead of print]. PMID: 24607939.

Ni Z, Tang J, Cai Z, et al. A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression. Respir Res. 2011 Apr 14;12:47. PMID: 21489309.

Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32. PMID: 21126634.