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M2698 is a dual inhibitor of p70S6K and Akt. In cancers with dysregulation of the PI3K/Akt/mTOR signaling pathway, M2698 demonstrates tumor growth inhibition, such as in mouse xeongraft models of triple-negative and Her-2 expressing breast cancer cell lines.
| Cas No. | 1379545-95-5 |
|---|---|
| Purity | ≥99% |
| Formula | C21H19ClF3N5O |
| Formula Wt. | 449.86 |
| Chemical Name | M2698 |
| IUPAC Name | 4-({(1S)-2-(1-Azetidinyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl}amino)-8-quinazolinecarboxamide |
| Synonym | M 2698, M-2698, MSC-2363318A |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Machl A., Wilker E., et al. M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. Am J Cancer Res. 6(4):806-18 (2016).