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Fumitremorgin C is a mycotoxin found in Aspergillus and Penicillum that inhibits ATP-binding cassette G2 (ABC-G2), a protein associated with multidrug resistance. Fumitremorgin C inhibits proliferation and viability of kidney side population cells.
| Cas No. | 118974-02-0 |
|---|---|
| Purity | ≥98% |
| Formula | C22H25N3O3 |
| Formula Wt. | 379.46 |
| Chemical Name | (5aS,12S,14aS)-9-Methoxy-12-(2-methyl-1-propen-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione |
| IUPAC Name | (5aS,12S,14aS)-9-Methoxy-12-(2-methyl-1-propen-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione |
| Solubility | Soluble in DMSO, methanol, acetone, DMF or chloroform. |
| Appearance | White to light brown powder. |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Dame ZT, Suwannarach N, Lumyong S, et al. A new citrinin dimer isolated from Aspergillus terreus strain ZDF21. Nat Prod Commun. 2015 Apr;10(4):623-4. PMID: 25973492.
Xie J, Jin B, Li DW, et al. ABCG2 regulated by MAPK pathways is associated with cancer progression in laryngeal squamous cell carcinoma. Am J Cancer Res. 2014 Nov 19;4(6):698-709. PMID: 25520861.
Liu HB, Meng QH, Du DW, et al. The effects of ABCG2 on the viability, proliferation and paracrine actions of kidney side population cells under oxygen-glucose deprivation. Int J Med Sci. 2014 Jul 20;11(10):1001-8. PMID: 25076846.
