LKT Labs

Biochemicals for Life Science Research

Adrenocorticotropic Hormone (1-4)

Product ID A0962
Cas No. 19405-50-6
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $44.50 In stock
2 mg $74.10 Please Inquire
5 mg $133.30 In stock
Bulk Quote

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Description

Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory activities. ACTH decreases inflammatory cytokine levels and modulates lymphocyte and macrophage functions. In vitro, ACTH stimulates proliferation of osteoblasts and increases mRNA levels of collagen I.

Product Info

Cas No.

19405-50-6
Purity

≥95%
Formula

C20H30N4O8S
Formula Wt.

486.6
IUPAC Name

(2S)-2-[[(2S)-2-[[(2S,5R)-2,5-diamino-6-hydroxy-3-(4-hydroxyphenyl)-4-oxohexanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoic acid
Synonym

ACTH

Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A0962 MSDS PDF
Info Sheet

A0962 Info Sheet PDF

References

Berkovich R, Agius MA. Mechanisms of action of ACTH in the management of relapsing forms of multiple sclerosis. Ther Adv Neurol Disord. 2014 Mar;7(2):83-96. PMID: 24587825.

Isales CM, Zaidi M, Blair HC. ACTH is a novel regulator of bone mass. Ann N Y Acad Sci. 2010 Mar;1192:110-6. PMID: 20392225.

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