• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
(E,Z)-4-Hydroxytamoxifen

(E,Z)-4-Hydroxytamoxifen

Product ID H9716
Cas No. 68392-35-8
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $58.30 In stock
10 mg $98.50 In stock
25 mg $200.70 In stock
100 mg $551.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

(E,Z)-4-Hydroxytamoxifen is a mixture of cis- and trans-isomers of 4-hydroxytamoxifen. 4-Hydroxytamoxifen is the active metabolite of tamoxifen, a selective estrogen receptor modulator (SERM) that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen exhibits anticancer chemotherapeutic activity, inducing autophagy and vacuole formation as well as KRAS degradation in various cancer cell lines. In cardiac myocytes, 4-hydroxytamoxifen decreases Ca2+ amplitude, slowing relaxation and decreasing contractility.

Product Info

Cas No.

68392-35-8

Purity

≥97%

Formula

C26H29NO2

Formula Wt.

387.51

IUPAC Name

4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

Synonym

Afimoxifene

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H9716 MSDS PDF

Info Sheet

H9716 Info Sheet PDF

References

Zhao Z, Wang B, Wu S, et al. Regulated control of virus replication by 4-hydroxytamoxifen-induced splicing. Front Microbiol. 2023 Mar 13:1112580. PMID: 36992923.

Asp ML, Martindale JJ, Metzger JM. Direct, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handling. PLoS One. 2013 Oct 24;8(10):e78768. PMID: 24205315.

Kohli L, Kaza N, Coric T, et al. 4-Hydroxytamoxifen induces autophagic death through K-Ras degradation. Cancer Res. 2013 Jul 15;73(14):4395-405. PMID: 23722551.

Schwartz JA, Zhong L, Deighton-Collins S, et al. Mutations targeted to a predicted helix in the extreme carboxyl-terminal region of the human estrogen receptor-alpha alter its response to estradiol and 4-hydroxytamoxifen. J Biol Chem. 2002 Apr 12;277(15):13202-9. Erratum in: J Biol Chem 2002 Jul 5;277(27):24842. PMID: 11823467.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C2540

    CGK 733

    ATM and ATR inhibitor.

    ≥98%
  • M578522

    Monascin

    Fungal pigment found in red yeast rice

    ≥98%
  • A2048

    Aflatoxin G1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • C179602

    CEP-28122

    ALK inhibitor.

    ≥98%
  • M0126

    Magainin 2

    Antimicrobial peptide found in frogs, induces p...

    ≥95%
  • G1853

    Genipin

    Iridoid glycoside found in Gardinia jasminoides...

    ≥99%
  • C0255

    Cantharidin

    Toxin produced by Canarthis vesicatoria; PP1/2A...

    ≥98%
  • T0092

    1-Hydroxybaccatin I

    Diterpene found in Taxus; potential microtubule...

    ≥98%
  • P3463

    Piperacillin Sodium

    β-lactam; penicillin binding protein inhibitor...

    ≥95%
  • T1024

    Baccatin VI

    Fermentation impurity

    ≥98%
  • F0048

    Famciclovir

    Penciclovir prodrug, nucleoside (guanosine) ana...

    ≥98%
  • M5753

    Monensin Sodium

    Polyether ionophore, autophagy inhibitor.

    ≥98%
  • A9715

    AZD-8330

    MEK 1/2 inhibitor.

    ≥98%
  • T1855

    Tentoxin

    Cyclic peptide mycotoxin produced by Alternaria...

    ≥98%, HPLC
  • D004098

    Dacomitinib Anhydrous

    EGFR inhibitor.

    ≥99%
  • D5792

    Doxofylline

    Xanthine derivative; PDE inhibitor.

    ≥98%
  • T3468

    Tirapazamine

    Topoisomerase II inhibitor, RPA modulator.

    ≥98%
  • N0068

    Naringenin

    Flavanone found in species of Citrus. Naringen...

    ≥98%
  • D3227

    Dihydromethysticin

    Kavalactone originally found in Piper methystic...

    ≥97%
  • D760022

    DT-2216

    BCL-XL specific degrader

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only