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Monensin Sodium

Product ID M5753
Cas No. 22373-78-0
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $51.30 In stock
1 g $73.50 In stock
5 g $257.40 In stock
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  • Description
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Description

Monensin is a polyether antibiotic initially produced by Streptomyces that exhibits antibactieral and anti-parasitic activities. Monensin is commercially used in cattle feed; it acts as an ionophore, transporting cations across cell membranes. Monensin inhibits autophagy, interfering with the fusion of the autophagosome and the lysosome.

Product Info

Cas No.

22373-78-0

Purity

≥98%

Formula

C36H61O11 Na

Formula Wt.

692.86

Chemical Name

2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetra- hydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl- 2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β- methoxy-α,γ,2,8-tetramethyl-1,6-dioxaspiro[4.5]- decane-7-butyric acid sodium salt

IUPAC Name

sodium;(2R,3S,4R)-4-[(2R,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2S,3R, 5S)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3, 5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2, 8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate

Synonym

Monensin sodium salt, Coban, Romemsin, Rumensin

Melting Point

267-269°C

Solubility

Insoluble in water. Soluble in DMSO, ethanol, methanol, chloroform, other organic solvents.

Appearance

A White or Almost White Crystalline Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

M5753 MSDS PDF

Info Sheet

M5753 Info Sheet PDF

References

Choi HS, Jeong EH, Lee TG, et al. Autophagy Inhibition with Monensin Enhances Cell Cycle Arrest and Apoptosis Induced by mTOR or Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cells. Tuberc Respir Dis (Seoul). 2013 Jul;75(1):9-17. PMID: 23946753.

Lavine MD, Arrizabalaga G. Analysis of monensin sensitivity in Toxoplasma gondii reveals autophagy as a mechanism for drug induced death. PLoS One. 2012;7(7):e42107. PMID: 22848721.

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