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Diallyl Sulfide

Product ID D3201
Cas No. 592-88-1
Purity ≥97%
Product Unit SizeCostQuantityStock
25 ml $81.90 In stock
100 ml $272.50 In stock
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Description

Diallyl sulfide is an organosulfur initially found in garlic; it exhibits anticancer chemotherapeutic, chemopreventive, neuroprotective, anti-inflammatory, antioxidative, anti-angiogenic, and anti-metastatic activities. Diallyl sulfide decreases DES-induced DNA damage and carcinogenesis in vitro and in vivo; it also inhibits the development of colon polyps in other carcinogenesis models. In animal models of cerebral ischemia/reperfusion, diallyl sulfide decreases infarct volume, apoptosis, and caspase 3 activation and increases levels of Bcl-2. In vitro, this compound decreases TNF-α-induced activation of NF-κB and suppresses histamine-induced levels of ROS, IL-1β, and TNF-α. Like other organosulfurs, diallyl sulfide induces phase II enzymes, increasing glutathione-S-transferase, glutathione reductase, superoxide dismutase, catalase, glutathione peroxidase, and Nrf2 in vivo. In animal models of osteosarcoma, diallyl sulfide decreases VEGF levels, microvessel density, cellular invasion, and tumor growth.

Product Info

Cas No.

592-88-1

Purity

≥97%

Formula

C6H10S

Formula Wt.

114.21

Chemical Name

Di-2-propenyl sulfide

IUPAC Name

3-prop-2-enylsulfanylprop-1-ene

Synonym

2-Propenyl sulphide, 3,3-Thiobis(1-propene), Diallyl monosulfide, Diallyl thioether, Allyl monosulfide, Allyl sulfide

Melting Point

-83°C

Solubility

Insoluble in water.

Appearance

Clear, Colorless liquid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3201 MSDS PDF

Info Sheet

D3201 Info Sheet PDF

Brochures

Natural Products Flyer

References

McCaskill ML, Rogan E, D Thomas R. Diallyl sulfide inhibits diethylstilbestrol induced DNA damage in human breast epithelial cells (MCF-10A). Steroids. 2014 Sep 30. [Epub ahead of print]. PMID: 25278253.

Ho CY, Weng CJ, Jhang JJ, et al. Diallyl sulfide as a potential dietary agent to reduce TNF-α- and histamine-induced proinflammatory responses in A7r5 cells. Mol Nutr Food Res. 2014 May;58(5):1069-78. PMID: 24415531.

Hu Y, Chen L, Yi C, et al. Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells. J Huazhong Univ Sci Technolog Med Sci. 2012 Aug;32(4):581-5. PMID: 22886974.

Kang JS, Kim TM, Shim TJ, et al. Modifying effect of diallyl sulfide on colon carcinogenesis in C57BL/6J-ApcMin/+ mice. Asian Pac J Cancer Prev. 2012;13(4):1115-8. PMID: 22799291.

Lin X, Yu S, Chen Y, et al. Neuroprotective effects of diallyl sulfide against transient focal cerebral ischemia via anti-apoptosis in rats. Neurol Res. 2012 Jan;34(1):32-7. PMID: 22196859.

Ho CY, Cheng YT, Chau CF, et al. Effect of diallyl sulfide on in vitro and in vivo Nrf2-mediated pulmonic antioxidant enzyme expression via activation ERK/p38 signaling pathway. J Agric Food Chem. 2012 Jan 11;60(1):100-7. PMID: 22118872.

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