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NAP Peptide

NAP Peptide

Product ID N0160
Cas No. 211439-12-2
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $51.10 In stock
1 mg $86.90 In stock
2.5 mg $153.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NAP is an octapeptide derived from activity-dependent neuroprotective protein (ADNP); it exhibits neuroprotective, antioxidative, cognition enhancing, anti-aging, and antipsychotic activities. NAP increases levels of Bcl-2 and activates MAPK/ERK signaling in retinal cells of diabetic mice, preventing retinal apoptosis. NAP also increases expression of Nrf2, heme oxygenase-1 (HO-1), glutathione transferase, and superoxide dismutase 1 (SOD1) in vivo, protecting against oxidative stress and improving memory performance in the radial arm maze. NAP decreases phosphorylation of tau protein in animal models of amyotrophic lateral sclerosis (ALS), protecting spinal cord motor neurons and increasing life span. NAP shows some clinical benefit in the treatment of neurodegenerative diseases such as ALS and progressive supranuclear palsy (PSP). Additionally, this peptide also inhibits cognitive dysfunction in animal models of schizophrenia.

Product Info

Cas No.

211439-12-2

Purity

≥95%

Formula

C36H60N10O12

Formula Wt.

824.94

IUPAC Name

L-Asparaginyl-L-alanyl-L-prolyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-glutamine

Synonym

Davunetide

Solubility

Soluble in DMSO.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N0160 MSDS PDF

Info Sheet

N0160 Info Sheet PDF

References

Scuderi S, D'Amico AG, Castorina A, et al. Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death. J Mol Neurosci. 2014 Feb 2. [Epub ahead of print]. PMID: 24488575.

Jouroukhin Y, Ostritsky R, Assaf Y, et al. NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport. Neurobiol Dis. 2013 Aug;56:79-94. PMID: 23631872.

Gold M, Lorenzl S, Stewart AJ, et al. Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy. Neuropsychiatr Dis Treat. 2012;8:85-93. PMID: 22347799.

Sharma NK, Sethy NK, Meena RN, et al. Activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) ameliorates hypobaric hypoxia induced oxidative stress in rat brain. Peptides. 2011 Jun;32(6):1217-24. PMID: 21453737.

Merenlender-Wagner A, Pikman R, Giladi E, et al. NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse--a microtubule-deficient model of schizophrenia. Peptides. 2010 Jul;31(7):1368-73. PMID: 20417241.

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