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Febuxostat

Febuxostat

Product ID F1607
Cas No. 144060-53-7
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $54.60 In stock
250 mg $107.80 In stock
1 g $287.20 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Febuxostat displays a variety of beneficial properties, including anti-inflammatory, anti-hyperuricemic, antidepressant, and nephroprotective activities. Febuxostat inhibits xanthine oxidase, preventing the generation of uric acid; as a result, it is used clinically to treat gout. In vitro, febuxostat inhibits MCP-1 and ROS production through activation of MAPK phosphatase. In vivo, febuxostat decreases oxidative stress and endoplasmic reticular stress, preventing increases in serum creatine and occurrence of renal tubular injury and fibrosis during renal ischemia. Additionally, this compound decreased immobility time during a forced swim test in animal models of depression.

Product Info

Cas No.

144060-53-7

Purity

≥98%

Formula

C16H16N2O3S

Formula Wt.

316.37

Chemical Name

2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid

IUPAC Name

2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F1607 MSDS PDF

Info Sheet

F1607 Info Sheet PDF

References

Nomura J, Busso N, Ives A, et al. Febuxostat, an Inhibitor of Xanthine Oxidase, Suppresses Lipopolysaccharide-Induced MCP-1 Production via MAPK Phosphatase-1-Mediated Inactivation of JNK. PLoS One. 2013 Sep 25;8(9):e75527. PMID: 24086554.

Karve AV, Jagtiani SS, Chitnis KA. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7. PMID: 23833366.

Tsuda H, Kawada N, Kaimori JY, et al. Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress. Biochem Biophys Res Commun. 2012 Oct 19;427(2):266-72. PMID: 22995295.

Bisht M, Bist SS. Febuxostat: a novel agent for management of hyperuricemia in gout. Indian J Pharm Sci. 2011 Nov;73(6):597-600. PMID: 23112391.

Custom Order

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