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Nefiracetam

Nefiracetam

Product ID N1721
Cas No. 77191-36-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $126.50 In stock
250 mg $253.50 In stock
1 g $774.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nefiracetam is pyrrolidone derivative that acts as an agonist at NMDA receptors, metabotropic glutamate receptors (mGluR5), and N-type and L-type voltage-gated Ca2+ channels. Nefiracetam also potentiates acetylcholine (ACh) currents via activity at α4β2 nicotinic acetylcholine receptors (nAChRs). Nefiracetam exhibits antiepileptic/anticonvulsant, neuroprotective, and cognition enhancing (nootropic) activities. In vivo, nefiracetam decreases seizure frequency and duration and also protects against neuronal death in animal models of post-ischemic seizure. In other animal models, this compound restored LTP, improved spatial memory, and improved object recognition in several behavioral assays, likely through glutamate-dependent modulation of PKC and CaMKII signaling.

Product Info

Cas No.

77191-36-7

Purity

≥98%

Formula

C14H18N2O2

Formula Wt.

246.3

Chemical Name

N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide

IUPAC Name

N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide

Synonym

DM-9384

Melting Point

151-155°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N1721 MSDS PDF

Info Sheet

N1721 Info Sheet PDF

References

Lu XC, Dave JR, Chen Z, et al. Nefiracetam attenuates post-ischemic nonconvulsive seizures in rats and protects neuronal cell death induced by veratridine and glutamate. Life Sci. 2013 Jun 13;92(22):1055-63. PMID: 23603142.

Malykh AG, Sadaie MR. Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders. Drugs. 2010 Feb 12;70(3):287-312. PMID: 20166767.

Moriguchi S, Han F, Shioda N, et al. Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice. J Neurochem. 2009 Jul;110(1):170-81. PMID: 19457128.

Kitano Y, Komiyama C, Makino M, et al. Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats. Brain Res. 2005 Sep 28;1057(1-2):168-76. PMID: 16122714.

Narahashi T, Moriguchi S, Zhao X, et al. Mechanisms of action of cognitive enhancers on neuroreceptors. Biol Pharm Bull. 2004 Nov;27(11):1701-6. PMID: 15516710.

Yoshii M, Watabe S, Murashima YL, et al. Cellular mechanism of action of cognitive enhancers: effects of nefiracetam on neuronal Ca2+ channels. Alzheimer Dis Assoc Disord. 2000;14 Suppl 1:S95-102. PMID: 10850736.

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