• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
PR-619

PR-619

Product ID P7000
Cas No. 2645-32-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $59.30 In stock
5 mg $126.50 In stock
25 mg $295.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PR-619 inhibits deubiquitinating enzymes (DUBs) and is used to study the role of ubiquitination in neurodegenerative diseases. This compound displays anti-inflammatory activity, inhibiting secretion of IL-1β in macrophages. In oligodendrocytes, PR-619 activates autophagy and aggrosome formation, stabilizes the microtubule network, and induces stress responses.

Product Info

Cas No.

2645-32-1

Purity

≥98%

Formula

C7H5N5S2

Formula Wt.

223.27

Chemical Name

2,6-Diamino-3,5-pyridinediyl bis(thiocyanate)

IUPAC Name

2,6-Diamino-3,5-pyridinediyl bis(thiocyanate)

Synonym

2,6-Diamino-3,5-dithiocyanopyridine

Solubility

DMSO 45 mg/mL Water Insoluble Ethanol Insoluble

Appearance

yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P7000 MSDS PDF

Info Sheet

P7000 Info Sheet PDF

References

Zhou Y, Zhao D, Yue R, et al. Inflammasomes-dependent regulation of IL-1β secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages. Antonie Van Leeuwenhoek. 2015 Jul;108(1):163-71. PMID: 25980833.

Seiberlich V, Borchert J, Zhukareva V, et al. Inhibition of protein deubiquitination by PR-619 activates the autophagic pathway in OLN-t40 oligodendroglial cells. Cell Biochem Biophys. 2013 Sep;67(1):149-60. PMID: 23686611.

Seiberlich V, Goldbaum O, Zhukareva V, et al. The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim Biophys Acta. 2012 Nov;1823(11):2057-68. PMID: 22565157.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • Z0252

    Zanamivir

    Neuraminidase inhibitor.

    ≥98%
  • P6957

    Protopanaxadiol

    Triterpene sapogenin found in species of Panax;...

    ≥98%
  • C4656

    Clopidol

    Coccidiostat.

    ≥98%
  • F5745

    Folic Acid

    Non-endogenous essential vitamin (B9), found in...

    ≥96%
  • T0110

    Taxane Standard Mixture

    Mixture of taxanes.

    ≥98%
  • L1983

    Leucomyosuppressin

    Peptide found in insects.

    ≥95%
  • S3352

    Sinefungin

    S-adenosylmethionine nucleoside analog; methylt...

    ≥95%
  • N3278

    7-Nitroindazole

    nNOS inhibitor.

    ≥98%
  • E543721

    Ensartinib

    A third-generation ALK inhibitor.

    ≥98%
  • E537332

    Enniatin A

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • M1873

    S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine

    Sulforaphane-cysteine conjugate.

    ≥98%
  • A1592

    ADX-47273

    mGluR5 positive modulator.

    ≥98%
  • R2710

    Recombinant Multi-epitope Chimeric HCV Antigen

    Recombinant Multi-epitope Chimeric HCV antigen....

    ≥95%
  • C6956

    Crotamiton

    Antipruritic.

    ≥98%
  • C9808

    CZC-54252

    LRRK2 inhibitor.

    ≥98%
  • B6816

    Brefeldin A

    Lactone found in fungi such as Eupenicillium; g...

    ≥97%
  • T5610

    γ-Tocotrienol

    Antioxidant, vitamin E derivative found in vege...

    ≥98%
  • I7468

    Isradipine

    Calcium channel blocker.

    ≥98%
  • P3441

    PIK-294

    p110δ PI3K inhibitor.

    ≥98%
  • P1753

    Penicillamine

    Penicillin derivative, chelating agent; carboxy...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only