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PR-619 inhibits deubiquitinating enzymes (DUBs) and is used to study the role of ubiquitination in neurodegenerative diseases. This compound displays anti-inflammatory activity, inhibiting secretion of IL-1β in macrophages. In oligodendrocytes, PR-619 activates autophagy and aggrosome formation, stabilizes the microtubule network, and induces stress responses.
| Cas No. | 2645-32-1 |
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| Purity | ≥98% |
| Formula | C7H5N5S2 |
| Formula Wt. | 223.27 |
| Chemical Name | 2,6-Diamino-3,5-pyridinediyl bis(thiocyanate) |
| IUPAC Name | 2,6-Diamino-3,5-pyridinediyl bis(thiocyanate) |
| Synonym | 2,6-Diamino-3,5-dithiocyanopyridine |
| Solubility | DMSO 45 mg/mL Water Insoluble Ethanol Insoluble |
| Appearance | yellow powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhou Y, Zhao D, Yue R, et al. Inflammasomes-dependent regulation of IL-1β secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages. Antonie Van Leeuwenhoek. 2015 Jul;108(1):163-71. PMID: 25980833.
Seiberlich V, Borchert J, Zhukareva V, et al. Inhibition of protein deubiquitination by PR-619 activates the autophagic pathway in OLN-t40 oligodendroglial cells. Cell Biochem Biophys. 2013 Sep;67(1):149-60. PMID: 23686611.
Seiberlich V, Goldbaum O, Zhukareva V, et al. The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim Biophys Acta. 2012 Nov;1823(11):2057-68. PMID: 22565157.