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Triclosan is a diarylether antimicrobial often found in commercial soap products. Triclosan exhibits antibacterial, antifungal, antiviral, and anti-inflammatory activities. Triclosan binds bacterial enoyl-acer carrier protein reductase (ENR), increasing its affinity for NAD+ and forming a complex that prevents fatty acid synthesis and bacterial cell membrane formation. Triclosan also inhibits LPS-induced pro-inflammatory responses in epithelial cells.
| Cas No. | 3380-34-5 |
|---|---|
| Purity | ≥98% |
| Formula | C12H7Cl3O2 |
| Formula Wt. | 289.54 |
| IUPAC Name | 5-chloro-2-(2,4-dichlorophenoxy)phenol |
| Solubility | Soluble in water (12 mg/ml at 20° C), methanol, chloroform, DMSO, and acetone |
| Appearance | White Crystal Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Wallet MA, Calderon Nl, Alonso TR, et al. Triclosan alters antimicrobial and inflammatory responses of epithelial cells. Oral Dis. 2013 Apr;19(3):296-302. PMID: 24079913.
Twanabasu BR, Smith CM, Stevens KJ, et al. Triclosan inhibits arbuscular mycorrhizal colonization in three wetland plants. Sci Total Environ. 2013 Mar 1;447:450-7. PMID: 23410867.
Russell AD. Whither triclosan? J Antimicrob Chemother. 2004 May;53(5):693-5. PMID: 15073159.