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Tetrahydroberberine

Product ID T1978
Cas No. 522-97-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $49.60 In stock
5 mg $124.00 In stock
25 mg $471.30 In stock
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  • References
  • Description
  • Product Info
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Description

Tetrahydroberberine (THB) is an isoquinoline alkaloid originally found in Corydalis. THB exhibits antithrombotic/anticoagulant, anti-arrhythmic, neuroprotective, and gastric motility-modulating activities. In vitro, THB inhibits tissue factor pro-coagulant activity; in vivo, it inhibits arachidonic acid-induced platelet aggregation. In animal models of cardiac ischemia/reperfusion, THB decreases levels of xanthine oxidase and malondialdehyde, decreasing ventricular tachycardia and ventricular fibrillation. In neurons, THB exhibits potential benefit in animal models of Parkinson’s disease, inhibiting K(ATP) K+ channels and increasing firing of action potentials. THB also inhibits D2 dopaminergic receptors and activates 5-HT1A receptors, increasing gastric emptying in animal models and displaying potential benefit in the treatment of functional dyspepsia.

Product Info

Cas No.

522-97-4

Purity

≥98%

Formula

C20H21NO4

Formula Wt.

339.39

Solubility

10 mM in DMSO insoluble in water

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

T1978 MSDS PDF

Info Sheet

T1978 Info Sheet PDF

References

Ge HX, Zhang J, Chen L, et al. Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. Bioorg Med Chem. 2013 Jan 1;21(1):62-9. PMID: 23199480.

Lee TH, Kim KH, Lee SO, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24. PMID: 21659472.

Wu C, Yang K, Liu Q, et al. Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta. Neuropharmacology. 2010 Dec;59(7-8):567-72. PMID: 20804776.

Xuan B, Wang W, Li DX. Inhibitory effect of tetrahydroberberine on platelet aggregation and thrombosis. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):133-5. PMID: 8010106.

Zhou J, Xuan B, Li DX. Effects of tetrahydroberberine on ischemic and reperfused myocardium in rats. Zhongguo Yao Li Xue Bao. 1993 Mar;14(2):130-3. PMID: 8352004.

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