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Asiatic Acid, 95%

Product ID A7332
Cas No. 464-92-6
Purity ≥95%
Product Unit SizeCostQuantityStock
100 mg $59.50 In stock
500 mg $204.10 In stock
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  • Description
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Description

Asiatic acid is a triterpene aglycone originally found in Centella; it exhibits cardioprotective, hepatoprotective, anti-inflammatory, antioxidative, antihypertensive, anticancer, anti-fibrotic, and anti-osteoporotic activities. In vitro and in vivo, asiatic acid inhibits TGF-β1-induced and overload-induced cardiac hypertrophy, decreasing production of TGF-β1 and activation of NF-κB, ERK1/2, and p38 MAPK. In high fat diet-fed rats, asiatic acid decreases expression of NF-κB, p38 MAPK, IL-1β, ROS, IL-6, and TNF-α and increases activity of glutathione peroxidase and catalase, preventing hepatic steatosis. Additionally, asiatic acid inhibits L-NAME-induced hypertension, increasing levels of NO and improving vascular function. In multiple myeloma cells, this compound induces G2/M phase cell cycle arrest, decreases expression of FAK, and inhibits cell proliferation. Asiatic acid inhibits adipogenesis, suppresses activation of G3PDH, and modulates differentiation in bone marrow stromal cells. In animal models of fibrosis, this compound decreases tubular injury and fibroblast activation by suppressing activation of Smad2/3, regulating PPARγ activation, and decreasing levels of α-SMA and TGF-β1. It appears to be the most active ingredient in the extract of Centella asiatica.

Product Info

Cas No.

464-92-6

Purity

≥95%

Formula

C30H48O5

Formula Wt.

488.70

IUPAC Name

(1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10, 11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a, 7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid

Synonym

NSC 166063

Melting Point

325-330°C

Solubility

Ethanol 10 mg/mL, DMSO 20 mg/mL, DMF 20 mg/mL

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A7332 MSDS PDF

Info Sheet

A7332 Info Sheet PDF

References

Si L, Xu J, Yi C, et al. Asiatic acid attenuates cardiac hypertrophy by blocking transforming growth factor-β1-mediated hypertrophic signaling in vitro and in vivo. Int J Mol Med. 2014 Aug;34(2):499-506. PMID: 24827470.

Yan SL, Yang HT, Lee YJ, et al. Asiatic acid ameliorates hepatic lipid accumulation and insulin resistance in mice consuming a high-fat diet. J Agric Food Chem. 2014 May 21;62(20):4625-31. PMID: 24779966.

Bunbupha S, Pakdeechote P, Kukongviriyapan U, et al. Asiatic Acid Reduces Blood Pressure by Enhancing Nitric Oxide Bioavailability with Modulation of eNOS and p47 phox Expression in l-NAME-induced Hypertensive Rats. Phytother Res. 2014 Apr 11. [Epub ahead of print]. PMID: 24723332.

Li ZW, Piao CD, Sun HH, et al. Asiatic acid inhibits adipogenic differentiation of bone marrow stromal cells. Cell Biochem Biophys. 2014 Mar;68(2):437-42. PMID: 23934183.

Zhang J, Ai L, Lv T, et al. Asiatic acid, a triterpene, inhibits cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells. Oncol Lett. 2013 Dec;6(6):1762-1766. PMID: 24260073.

Bian D, Zhang J, Wu X, et al. Asiatic acid isolated from Centella asiatica inhibits TGF-β1-induced collagen expression in human keloid fibroblasts via PPAR-γ activation. Int J Biol Sci. 2013 Oct 25;9(10):1032-42. PMID: 24250248.

Xu C, Wang W, Xu M, et al. Asiatic acid ameliorates tubulointerstitial fibrosis in mice with ureteral obstruction. Exp Ther Med. 2013 Sep;6(3):731-736. PMID: 24137256.

Juraiporn Somboonwong, Mattana Kankaisre, Boonyong Tantisira, and Mayuree H Tantisira, Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study. BMC Complement Altern Med. 2012; 12: 103. PMCID: PMC3492213

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