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Phenylhexyl Isothiocyanate

Phenylhexyl Isothiocyanate

Product ID P2922
Cas No. 133920-06-6
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $112.60 In stock
100 mg $206.00 In stock
250 mg $412.50 In stock
500 mg $619.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Isothiocyanates are compounds typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and antibiotic properties. In vitro, phenhexyl isothiocyanate (PHITC) increases caspase 3 activity and cleavage of poly(ADP)-ribose polymerase (PARP), inducing caspase-mediated apoptosis in cellular models. This compound decreases oxidation of carcinogen NNK and increases activity of NADPH:quinone oxidoreductase and glutathione S-transferase in vitro and in vivo. PHITC inhibits histone deacetylase (HDAC) activity, IL-6 receptor production, and VEGF expression; it also induces mitochondrial membrane depolarization and apoptosis in myeloma cells. In leukemia cells, PHITC inhibits expression of cyclin and increases expression of cyclin dependent kinase (CDK) inhibitors, inducing apoptosis and inhibiting growth of xenografts of these cells in animals.

Product Info

Cas No.

133920-06-6

Purity

≥98%

Formula

C13H17NS

Formula Wt.

219.35

IUPAC Name

6-isothiocyanatohexylbenzene

Synonym

6-Phenylhexyl isothiocyanate, PHITC

Solubility

Soluble in oraganic solvents.

Appearance

Clear colorless liquid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P2922 MSDS PDF

Info Sheet

P2922 Info Sheet PDF

References

Lu Q, Lin X, Feng J, et al. Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways. J Hematol Oncol. 2008 Jun 9;1:6. PMID: 18577263.

Lu L, Liu D, Ma X, et al. The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo. Oncol Rep. 2006 Dec;16(6):1363-7. PMID: 17089062.

Morse MA, Eklind KI, Hecht SS, et al. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 1991 Apr 1;51(7):1846-50. PMID: 2004368.

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