Clodronate Disodium Tetrahydrate

Name: Clodronate Disodium Tetrahydrate
SKU: C3449
Availability: InStock

Product ID C3449

Cas No. 88416-50-6

Purity ≥98%

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Product Info
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Description

Clodronate is a first-generation non-nitrogen-containing bisphosphonate that is used clinically for its anti-resorptive activity. Clodronate generates formation of a non-hydrolysable β-γ ATP analog that inhibits mitochondrial ADP/ATP translocase and prevents mitochondrial oxygen consumption and function; as a result, osteoblast calcium deposition is inhibited and apoptosis is induced in osteoclasts, inhibiting bone resorption. Clodronate also decreases expression of MMP9 and improves performance on the Rotarod test, decreasing severity of experimental autoimmune neuritis, an animal model of Guillan-Barre Syndrome. Additionally, clodronate exhibits anticancer chemotherapeutic and anti-angiogenic activities, decreasing vessel density in vivo and inhibiting cellular proliferation in models of renal cell carcinoma.

Product Info

Cas No.	88416-50-6
Purity	≥98%
Formula	CH₂Cl₂Na₂O₆P₂ • 4H₂O
Formula Wt.	360.92
Chemical Name	Clodronate disodium salt; Dichloromethylene- bisphophonate disodium tetrahydrate
IUPAC Name	disodium;[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
Synonym	Clodronic acid disodium salt, chlodronate sodium, clasteron
Solubility	Soluble in water to 100 mM
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C3449 MSDS PDF
Info Sheet	C3449 Info Sheet PDF

References

Katzav A, Bina H, Aronovich R, et al. Treatment for experimental autoimmune neuritis with clodronate (Bonefos). Immunol Res. 2013 Jul;56(2-3):334-40. PMID: 23579773.

Soltau J, Zirrgiebel U, Esser N, et al. Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model. Anticancer Res. 2008 Mar-Apr;28(2A):933-41. PMID: 18507039.

Kellinsalmi M, Mönkkönen H, Mönkkönen J, et al. In vitro comparison of clodronate, pamidronate and zoledronic acid effects on rat osteoclasts and human stem cell-derived osteoblasts. Basic Clin Pharmacol Toxicol. 2005 Dec;97(6):382-91. PMID: 16364054.

Reszka AA, Rodan GA. Mechanism of action of bisphosphonates. Curr Osteoporos Rep. 2003 Sep;1(2):45-52. PMID: 16036064.

Rogers MJ. New insights into the molecular mechanisms of action of bisphosphonates. Curr Pharm Des. 2003;9(32):2643-58. PMID: 14529538.

Lehenkari PP, Kellinsalmi M, Näpänkangas JP, et al. Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol Pharmacol. 2002 May;61(5):1255-62. PMID: 11961144.

Sato A, Nakashima H, Nakashima M, et al. Involvement of the TNF and FasL produced by CD11b Kupffer cells/macrophages in CCl4-induced acute hepatic injury. PLoS One. 2014 Mar 25;9(3):e92515. PMID: 24667392.

Kimura K, Nakamura Y, Inaba Y, et al. Histidine augments the suppression of hepatic glucose production by central insulin action. Diabetes. 2013 Jul;62(7):2266-2277. PMID: 23474485.