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Olomoucine

Product ID O4556
Cas No. 101622-51-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $103.60 In stock
25 mg $408.80 Please Inquire
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Olomoucine is a purine derivative that inhibits CDKs and exhibits anti-inflammatory, neuroprotective, and anticancer activities. In macrophages, olomoucine decreases levels of NO and iNOS and suppresses activation of NF-κB. In leukemia cells, olomoucine alters cell cycle progression and inhibits proliferation. Additionally, this compound prevents cathepsin L translocation and the induction of autophagy in neurons, protecting against 6-OHDA-induced toxicity.

Product Info

Cas No.

101622-51-9

Purity

≥98%

Formula

C15H18N6O

Formula Wt.

298.34

Chemical Name

6-Benylamino-2-(2-hydroxyethylamino)-9-methyl- purine

IUPAC Name

2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol

Synonym

2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine

Melting Point

120-130°C

Solubility

Soluble in DMSO or methanol.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

O4556 MSDS PDF

Info Sheet

O4556 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Wandl S, Wesierska-Gadek J. Is olomoucine, a weak CDK2 inhibitor, able to induce apoptosis in cancer cells? Ann N Y Acad Sci. 2009 Aug;1171:242-9. PMID: 19723061.

Fei XF, Qin ZH, Xiang B, et al. Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine. Brain Res. 2009 Apr 6;1264:85-97. PMID: 19368812.

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