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5-Fluorouracil (5-FU) is an antimetabolite pyrimidine analog that exhibits anticancer chemotherapeutic activity; it inhibits thymidylate synthase, preventing thymidine synthesis. 5-FU is clinically used to treat various cancers and is often co-administered with other chemotherapeutics to decrease its peripheral cytotoxicity.
| Cas No. | 51-21-8 |
|---|---|
| Purity | ≥98% |
| Formula | C4H3FN2O2 |
| Formula Wt. | 130.08 |
| Chemical Name | 5-Fluoro-2,4(1H,3H)-pyrimidinedione |
| IUPAC Name | 5-fluoro-1H-pyrimidine-2,4-dione |
| Synonym | Fluorouracil, 5-FU, 2,4-dioxo-5-fluoropyrimidine |
| Melting Point | 282-283°C(dec.) |
| Solubility | Slightly soluble in water (12 mg/mL). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Papanastasopoulos P, Stebbing J. Molecular basis of 5-fluorouracil-related toxicity: lessons from clinical practice. Anticancer Res. 2014 Apr;34(4):1531-5. PMID: 24692679.
Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003 May;3(5):330-8. PMID: 12724731.
