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Isoliquiritigenin, natural

Product ID I7559
Cas No. 961-29-5
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $88.60 In stock
5 mg $157.50 In stock
10 mg $277.70 In stock
25 mg $509.20 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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Description

Isoliquiritigenin is a chalcone with a wide variety of targets; it exhibits anticancer, anti-angiogenic, antioxidative, and neuroprotective activities. Isoliquiritigenin inhibits NMDA receptors, histone deacetylases (HDACs), VEGFR2, and NF-κB (via inhibition of IκB kinase). In vitro, this compound increases Nrf2 expression. Additionally, isoliquiritigenin downregulates expression of arachidonic acid-metabolizing enzymes cyclooxygenase-2 (COX-2) and phospholipase A2 (PLA2), increasing mitochondria- and/or caspase-mediated apoptosis, and inhibiting proliferation of breast cancer cells. Isoliquiritigenin also modulates sirtuins and acts as a positive allosteric modulator at GABA-A receptors.

Product Info

Cas No.

961-29-5

Purity

≥99%

Formula

C15H12O4

Formula Wt.

256.25

Chemical Name

(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one

IUPAC Name

(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

Synonym

4,2’,4’-Trihydroxychalcone

Appearance

Bright yellow powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

I7559 MSDS PDF

Info Sheet

I7559 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Chen H, Zhang B, Yuan X, et al. Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. Cell Biol Int. 2013 Nov;37(11):1215-1224. PMID: 23881796.

Wang Z, Wang N, Han S, et al. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. PLoS One. 2013 Jul 5;8(7):e68566. PMID: 23861918.

Li Y, Zhao H, Wang Y, et al. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):37-48. PMID: 23747687.

Yuan X, Zhang B, Gan L, et al. Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. Biomed Environ Sci. 2013 Apr;26(4):268-76. PMID: 23534467.

Orlikova B, Schnekenburger M, Zloh M, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. PMID: 22710558.

Cho S, Kim S, Jin Z, et al. Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. Biochem Biophys Res Commun. 2011 Oct 7;413(4):637-42. PMID: 21945440.

Kawakami Z, Ikarashi Y, Kase Y. Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. Cell Mol Neurobiol. 2011 Nov;31(8):1203-12. PMID: 21691759.

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