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ARRY-162

Product ID A6971
Cas No. 606143-89-9
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $61.50 In stock
25 mg $129.50 In stock
100 mg $340.70 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

ARRY-162 is an orally bioavailable noncompetitive inhibitor of MEK1/2 and ERK that shows anticancer chemotherapeutic activity. Inhibition of MEK inhibits downstream signaling by IL-1, IL-6, and TNF. ARRY-162 inhibits proliferation in melanoma, non-small-cell lung cancer (NSCLC), head/neck cancer, and pancreatic cancer models.

Product Info

Cas No.

606143-89-9

Purity

≥99%

Formula

C17H15BrF2N4O3

Formula Wt.

441.23

Chemical Name

6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3- methylbenzimidazole-5-carboxamide

IUPAC Name

6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3- methylbenzimidazole-5-carboxamide

Synonym

MEK162, MEK-162, Binimetinib

Solubility

DMSO 88 mg/mL warmed (199.44 mM) Water Insoluble Ethanol Insoluble

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A6971 MSDS PDF

Info Sheet

A6971 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

www.clinicaltrials.gov/show/NCT00959127

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St. Paul MN, 55130

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