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Spironolactone

Product ID S6235
Cas No. 52-01-7
Purity ≥97%
Product Unit SizeCostQuantityStock
250 mg $64.90 In stock
1 g $92.50 In stock
5 g $265.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Spironolactone is a diuretic that inhibits aldosterone receptors, mineralocorticoid receptors, androgen receptors, and endothelial Na+ channels (ENaCs). Spironolactone exhibits antihypertensive activity and is clinically used to treat heart failure. Spironolactone may inhibit voltage-gated Ca2+ channels.

Product Info

Cas No.

52-01-7

Purity

≥97%

Formula

C24H32O4S

Formula Wt.

416.57

Chemical Name

(7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4- ene-21-carboxylic acid γ-lactone

IUPAC Name

S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9, 11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17, 2'-oxolane]-7-yl] ethanethioate

Synonym

Spirolactone, Spiroctan, Aldactone

Melting Point

134-135°C (lit.)

Solubility

Soluble in organic solvents. Practically insoluble in water.

Appearance

Off-White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S6235 MSDS PDF

Info Sheet

S6235 Info Sheet PDF

References

Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013 Oct 15;62(16):e147-239. PMID: 23747642.

Mann SJ, Parikh NS. A simplified mechanistic algorithm for treating resistant hypertension: efficacy in a retrospective study. J Clin Hypertens (Greenwich). 2012 Apr;14(4):191-7. PMID: 22458739.

Nappi JM, Sieg A. Aldosterone and aldosterone receptor antagonists in patients with chronic heart failure. Vasc Health Risk Manag. 2011;7:353-63. PMID: 21731887.

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