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Aristolochic Acid A

Product ID A6932
Cas No. 313-67-7
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $111.30 In stock
5 mg $463.00 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

Aristolochic acid A is a carcinogenic compound found in Aristolochia and Radix that has commonly been used in traditional Chinese medicine. This compound inhibits phospholipase A2 (PLA2) and decreases GABA-induced release of arachidonic acid and phosphatidylcholine as well as exocytosis in vitro.

Product Info

Cas No.

313-67-7

Purity

≥95%

Formula

C17H11NO7

Formula Wt.

341.27

Chemical Name

8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid

IUPAC Name

8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid

Synonym

Aristolochic acid, Aristolochin Birthwort, Tardolyt

Melting Point

281-286°C(dec.)

Solubility

Soluble in DMSO or ethanol.

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A6932 MSDS PDF

Info Sheet

A6932 Info Sheet PDF

References

Chen WY, Ni Y, Pan YM, et al. GABA, progesterone and zona pellucida activation of PLA2 and regulation by MEK-ERK1/2 during acrosomal exocytosis in guinea pig spermatozoa. FEBS Lett. 2005 Aug 29;579(21):4692-700. PMID: 16098515.

Stiborová M, Frei E, Sopko B, et al. Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase. Carcinogenesis. 2003 Oct;24(10):1695-703. PMID: 12869422.

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