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Cordycepin

Cordycepin

Product ID C5968
Cas No. 73-03-0
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $112.20 In stock
25 mg $224.60 In stock
100 mg $561.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cordycepin is originally found in a variety of species of the fungus Cordyceps and displays anticancer, neuromodulatory, anti-inflammatory, anti-parasitic, and antiviral activities. Cordycepin induces double-stranded DNA breaks in cancer cells with incorporated into nucleic acid chains as it is a 3-deoxy analog of adenosine. Additionally, cordycepin increases generation of reactive oxygen species (ROS), increases caspase activity and PARP cleavage, and activates AMPK, inducing caspase-mediated apoptosis in cells. Cordycepin decreases the amplitude of excitatory presynaptic membrane potentials and indirectly inhibits AMPA receptor- and NMDA receptor-mediated responses through inhibition of presynaptic excitatory neurotransmitter release. In vitro, cordycepin decreases production of NO, activation of NF-κB, and expression of iNOS, COX-2, and TNF-α. This compound displays antimicrobial activity against Leishmania and also terminates RNA chains in cells infected with picornavirus.

Product Info

Cas No.

73-03-0

Purity

≥99%

Formula

C10H13N5O3

Formula Wt.

251.24

Chemical Name

3'-deoxyadenosine

IUPAC Name

(2R,3R,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol

Synonym

9-Cordyceposidoadenine

Solubility

Water

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C5968 MSDS PDF

Info Sheet

C5968 Info Sheet PDF

References

Yao LH, Huang JN, Li CH, et al. Cordycepin suppresses excitatory synaptic transmission in rat hippocampal slices via a presynaptic mechanism. CNS Neurosci Ther. 2013 Apr;19(4):216-21. PMID: 23419191.

Lee HJ, Burger P, Vogel M, et al. The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells. Invest New Drugs. 2012 Oct;30(5):1917-25. PMID: 22821173.

Jeong JW, Jin CY, Park C, et al. Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol In Vitro. 2011 Jun;25(4):817-24. PMID: 21310227.

Wang Z, Wang X, Qu K, et al. Binding of cordycepin monophosphate to AMP-activated protein kinase and its effect on AMP-activated protein kinase activation. Chem Biol Drug Des. 2010 Oct;76(4):340-4. PMID: 20738312.

Kim HG, Shrestha B, Lim SY, et al. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol. 2006 Sep 18;545(2-3):192-9. PMID: 16899239.

Wataya Y, Hiraoka O. 3'-Deoxyinosine as an anti-leishmanial agent: the metabolism and cytotoxic effects of 3'-deoxyinosine in Leishmania tropica promastigotes. Biochem Biophys Res Commun. 1984 Sep 17;123(2):677-83. PMID: 6487305.

Panicali DL, Nair CN. Effect of cordycepin triphosphate on in vitro RNA synthesis by picornavirus polymerase complexes. J Virol. 1978 Jan;25(1):124-8. PMID: 202731.

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