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Flavokawain B

Product ID F4503
Cas No. 1775-97-9
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $254.30 In stock
10 mg $392.80 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Flavokawain B is a chalcone kavalactone originally found in Piper methysticum (kava plant). Flavokawain B exhibits hepatotoxic and anti-inflammatory activities. This compound inhibits degradation of IκBα and activation of NF-κB.

Product Info

Cas No.

1775-97-9

Purity

≥97%

Formula

C17H16O4

Formula Wt.

284.31

IUPAC Name

(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one

Melting Point

85-87°C

Solubility

DMSO to 35 mM. Insoluble in water. Soluble in methanol.

Appearance

Orange/Yellow crystalline powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

F4503 MSDS PDF

Info Sheet

F4503 Info Sheet PDF

References

Teschke R, Qiu SX, Lebot V. Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. Dig Liver Dis. 2011 Sep;43(9):676-81. PMID: 21377431.

Folmer F, Blasius R, Morceau F, et al. Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives. Biochem Pharmacol. 2006 Apr 14;71(8):1206-18. PMID: 16464438.

Sakai T, Eskander RN, Guo Y, et al. Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. J Orthop Res. 2012 Jul;30(7):1045-1050. PMID: 22213202.

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