Description
Amikacin is an aminoglycoside antibiotic that exhibits antibacterial efficacy against gram negative bacteria. Amikacin binds the 30S ribosomal subunit, preventing translation.
Product Unit Size | Cost | Quantity | Stock |
---|
Amikacin is an aminoglycoside antibiotic that exhibits antibacterial efficacy against gram negative bacteria. Amikacin binds the 30S ribosomal subunit, preventing translation.
Cas No. | 39831-55-5 |
---|---|
Purity | ≥98% |
Formula | C22H43N5O13 • 2H2SO4 |
Formula Wt. | 781.76 |
Chemical Name | O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1->6)-O- [6-amino-6-deoxy-α-D-glucopyranosyl-(1->4)]-N1- [(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D- streptamine sulfate |
IUPAC Name | (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S, 6R)-6-(aminomethyl)-3,4, 5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide; sulfuric acid |
Synonym | Amikacin sulfate, Amikin, Biklin, Lukadin, Mikavir, Novamin, Pierami |
Melting Point | 220-230°C(dec.) |
Solubility | Soluble in water (50mg/mL). Insolulble in acetone and water. DMSO <1 mg/mL. |
Appearance | White or Almost White Powder |
Store Temp | Ambient |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Barza M, Scheife RT. Drug therapy reviews: Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics--part 4: aminoglycosides. Am J Hosp Pharm. 1977 Jul;34(7):723-37. PMID: 407790.
Kawaguchi H. Discovery, chemistry, and activity of amikacin. J Infect Dis. 1976 Nov;134 SUPPL:S242-8. PMID: 825583.
King P, Citron DM, Griffith DC, et al. Effect of oxygen limitation on the in vitro activity of levofloxacin and other antibiotics administered by the aerosol route against Pseudomonas aeruginosa from cystic fibrosis patients. Diagn Microbiol Infect Dis. 2010 Feb;66(2):181-186. PMID: 19828274.
α1-adrenergic antagonist.
ITC precursor found in cruciferous vegetables.<...
Deubiquitinating enzyme inhibitor.
Triterpenoid found in Centella.
Fermentation impurity
Statin; HMG-CoA reductase inhibitor, potential ...
Alkaloid compound originally found in Corydalis...
Isoflavone found in Pueraria; 5-HT2C and GABA-A...
Endogenous peptide hormone, involved in water h...
Promotes Aβ clearance.
Mouse selective STING agonist.
Trichothecene mycotoxin produced by Fusarium.
PKC and PKD activator, carcinogen.
EGFR and PDGFR inhibitor
Synthetic peptide; FPRL1 agonist.
ITC, erucin analog.
NSAID; COX-1/2 inhibitor.
Macrolide antibiotic; peptidyl transferase inhi...
Fluoroquinolone; bacterial DNA gyrase inhibitor...
Selective 5-HT6 receptor antagonist