• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register

Leflunomide

Product ID L1817
Cas No. 75706-12-6
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $92.50 In stock
500 mg $305.70 In stock
1 g $463.00 In stock
Bulk Quote
Add to Wishlist

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Leflunomide inhibits dihydroorotate dehydrogenase, preventing UMP formation and pyrimidine synthesis. Metabolites of leflunomide may inhibit various kinases such as JNK and JAK. Leflunomide is clinically used to treat rheumatoid arthritis; it exhibits immunosuppressive, antiviral, and anticancer activities. In several cellular models, leflunomide prevents apoptosis and increases viability in human cytomegalovirus (CMV)-infected cells and inhibits replication of polyomavirus BK. Additionally, leflunomide increases activity of aryl hydrocarbon receptors, inhibiting proliferation of melanoma cells.

Product Info

Cas No.

75706-12-6

Purity

≥98%

Formula

C12H9F3N2O2

Formula Wt.

270.21

Chemical Name

5-Methyl-N-[4-(trifluoromethyl)phenyl]-4- isoxazolecarboxamide

IUPAC Name

5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

Synonym

HWA-486, Arava

Melting Point

166.5°C

Solubility

Soluble in DMSO or methanol.

Appearance

White or off-white crystalline powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L1817 MSDS PDF

Info Sheet

L1817 Info Sheet PDF

References

Qi R, Hua-Song Z, Xiao-Feng Z. Leflunomide inhibits the apoptosis of human embryonic lung fibroblasts infected by human cytomegalovirus. Eur J Med Res. 2013 Feb 1;18:3. PMID: 23369524.

O'Donnell EF, Kopparapu PR, Koch DC, et al. The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells. PLoS One. 2012;7(7):e40926. PMID: 22815870.

Bernhoff E, Tylden GD, Kjerpeseth LJ, et al. Leflunomide inhibition of BK virus replication in renal tubular epithelial cells. J Virol. 2010 Feb;84(4):2150-6. PMID: 19955306.

Pinto P, Dougados M. Leflunomide in clinical practice. Acta Reumatol Port. 2006 Jul-Sep;31(3):215-24. PMID: 17094333.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2023 LKT Laboratories, All Rights Reserved - Products for research use only