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Deoxyandrographolide is a labdane diterpenoid found in Andrographis. This compound is an isoprenoid that inhibits PAF in neutrophils. Deoxyandrographolide exhibits antioxidative, vasodilatory, and hepatoprotective activities. This compound activates cNOS and adenylyl cyclase, decreasing oxidative stress and ethanol-induced hepatic injury in vivo. Additionally, this compound decreases perfusion pressure and dilates vessels in vivo; it may also inhibit voltage-gated Ca2+ channels.
| Cas No. | 4176-97-0 |
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| Purity | ≥98% |
| Formula | C20H30O4 |
| Formula Wt. | 334.45 |
| IUPAC Name | 4-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one |
| Melting Point | 176-178°C |
| Appearance | White crystalline powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Mandal S, Nelson VK, Mukhopadhyay S, et al. 14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats. Food Chem Toxicol. 2013 Sep;59:236-48. PMID: 23764359.
Awang K, Abdullah NH, Hadi AH, et al. Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts. J Biomed Biotechnol. 2012;2012:876458. PMID: 22536026.
Burgos RA, Hidalgo MA, Monsalve J, et al. 14-deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils. Planta Med. 2005 Jul;71(7):604-8. PMID: 16041644.
Burgos RA, Loyola M, Hidalgo MA, et al. Effect of 14-deoxyandrographolide on calcium-mediated rat uterine smooth muscle contractility. Phytother Res. 2003 Nov;17(9):1011-5. PMID: 14595578.