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Aceclofenac is a diclofenac analog that exhibits anti-inflammatory and analgesic activities. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that somewhat selectively inhibits COX-2; it is clinically used to treat rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Aceclofenac downregulates expression of L-selectin, ICAM-3, and CD43, decreasing neutrophil adhesion to endothelial cells.
| Cas No. | 89796-99-6 |
|---|---|
| Purity | ≥98% |
| Formula | C16H13Cl2NO4 |
| Formula Wt. | 354.18 |
| Chemical Name | 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester |
| IUPAC Name | 2-[2-[2-(2,6-dichloroanilino)phenyl]acetyl]oxyacetic acid |
| Synonym | Airtal, Falcol, Gerbin, Preservex |
| Melting Point | 149-150°C |
| Solubility | Soluble in ethanol and acetone, insoluble in water |
| Appearance | A White or Almost White Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Chopade AR, Sayyad FJ, Naikwade NS. Pharmacological characterization of carrageenan induced heat muscle hyperalgesia in rats using non-selective, preferential and selective COX-2 inhibitors. Pharmacol Rep. 2014 Jun;66(3):353-62. PMID: 24905509.
González-Alvaro I, Carmona L, Díaz-González F, et al. Aceclofenac, a new nonsteroidal antiinflammatory drug, decreases the expression and function of some adhesion molecules on human neutrophils. J Rheumatol. 1996 Apr;23(4):723-9. PMID: 8730134.
