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LMK-235

Product ID L493400
Cas No. 1418033-25-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $79.40 In stock
25 mg $340.20 In stock
100 mg $992.30 In stock
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  • Description
  • Product Info
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Description

LMK-235 is an HDAC inhibitor, selectively targeting HDAC4 and HDAC5. It induces apoptosis in multiple myeloma cells, a cancer type with a high rate of relapse. This activity is attributed to the downregulation of heme oxygenase-1 (HO-1), which is closely related to HDAC4, as well as increased phosphorylation of JNK.

Product Info

Cas No.

1418033-25-6

Purity

≥98%

Formula

C15H22N2O4

Formula Wt.

294.35

IUPAC Name

N-{[6-(Hydroxyamino)-6-oxohexyl]oxy}-3,5-dimethylbenzamide

Synonym

LMK235

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L493400 MSDS PDF

Info Sheet

L493400 Info Sheet PDF

References

Marek L., Hamacher A., et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J Med Chem. 56(2):427-36 (2013). PMID: 23252603.

Li X., Guo Y., et al. Histone deacetylase inhibitor LMK-235-mediated HO-1 expression induces apoptosis in multiple myeloma cells via the JNK/AP-1 signaling pathway. Life Sci. 223:146-157 (2019). PMID: 30876940.

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