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Miconazole

Miconazole

Product ID M3309
Cas No. 22916-47-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $66.90 In stock
5 g $188.00 In stock
25 g $300.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Miconazole is an imidazole antifungal compound that inhibits ergosterol synthesis and fungal cell wall formation. Miconazole is clinically used to treat fungal infections and is especially active against Candida. Miconazole also exhibits anti-angiogenic activities, decreasing expression of HIF-1α and VEGF in breast cancer and glioma cells. Additionally, this compound may inhibit glucocorticoid receptors.

Product Info

Cas No.

22916-47-8

Purity

≥98%

Formula

C18H14Cl4N2O

Formula Wt.

416.14

Chemical Name

1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)- methoxy]ethyl]-1H-imidazole

IUPAC Name

1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

Synonym

Monistat IV

Melting Point

84.3°C

Solubility

Practically insoluble in water. Soluble in ethanol (105 mg/mL), methanol (66 mg/mL).

Appearance

White to yellowish powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M3309 MSDS PDF

Info Sheet

M3309 Info Sheet PDF

References

Park JY, Jung HJ, Seo I, et al. Translational suppression of HIF-1α by miconazole through the mTOR signaling pathway. Cell Oncol (Dordr). 2014 Jul 29. [Epub ahead of print]. PMID: 25070654.

Niimi M, Firth NA, Cannon RD. Antifungal drug resistance of oral fungi. Odontology. 2010 Feb;98(1):15-25. PMID: 20155503.

Duret C, Daujat-Chavanieu M, Pascussi JM, et al. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol Pharmacol. 2006 Jul;70(1):329-39. PMID: 16608920.

Tatsumi Y, Nagashima M, Shibanushi T, et al. Mechanism of action of efinaconazole, a novel triazole antifungal agent. Antimicrob Agents Chemother. 2013 May;57(5):2405-2409. PMID: 23459486.

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