Levamisole Hydrochloride

Name: Levamisole Hydrochloride
SKU: L1682
Availability: InStock

Product ID L1682

Cas No. 16595-80-5

Purity ≥98%

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Product Info
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Description

Levamisole is an imidazothiazole that exhibits immunomodulatory, anti-parasitic, anti-helminthic, anti-angiogenic, and anticancer chemotherapeutic activities. Levamisole inhibits alkaline phosphatase and may act as an agonist at nicotinic acetylcholine receptors (nAChRs). In multiple myeloma cells, levamisole induces DNA fragmentation, cytochrome c release and caspase 3 activation, inhibiting cellular proliferation. In other models, levamisole also inhibits proliferation and differentiation of endothelial cells and suppresses growth of various tumors in vivo.

Product Info

Cas No.	16595-80-5
Purity	≥98%
Formula	C₁₁H₁₂N₂S • HCl
Formula Wt.	240.76
Chemical Name	Imidazo(2,1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (-)- (8CI)
IUPAC Name	(6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1, 3]thiazole;hydrochloride
Synonym	Tetramisole hydrochloride, Citarin L, Ergamisol, Spartakon
Melting Point	228-230°C
Solubility	Soluble in water.
Appearance	A white or almost white crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	L1682 MSDS PDF
Info Sheet	L1682 Info Sheet PDF

References

Ramanadham M, Nageshwari B. Anti-proliferative effect of levamisole on human myeloma cell lines in vitro. J Immunotoxicol. 2010 Oct-Dec;7(4):327-32. PMID: 20860474.

Friis T, Engel AM, Klein BM, et al. Levamisole inhibits angiogenesis in vitro and tumor growth in vivo. Angiogenesis. 2005;8(1):25-34. PMID: 16132615.

Zinser EW, Wolf ML, Alexander-Bowman SJ, et al. Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals. J Vet Pharmacol Ther. 2002 Aug;25(4):241-50. PMID: 12213111.

Van Belle H. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem. 1976 Jul;22(7):972-6. PMID: 6169.