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Baicalin

Product ID B0133
Cas No. 21967-41-9
Purity ≥95%
Product Unit SizeCostQuantityStock
250 mg $45.50 In stock
500 mg $64.90 In stock
1 g $84.40 In stock
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  • Product Info
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  • References
  • Description
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  • Downloads
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Description

Baicalin is a flavone found in Scutellaria that exhibits antiviral, antioxidative, antihypertensive, cardioprotective, anti-inflammatory, and anticancer chemotherapeutic activities. Baicalin inhibits prolyl oligopeptidase. Baicalin also inhibits neuraminidase, preventing influenza infection. In animal models of hypoxia-induced pulmonary arterial hypertension, baicalin decreases systolic blood pressure, inhibits ventricular remodeling, and suppresses proliferation of pulmonary artery smooth muscle cells. In animal models of cerebral hemorrhage, baicalin decreases development of edema and suppresses expression of matrix metalloproteinase 9 (MMP9), IL-6, and IL-1β. Additionally, baicalin inhibits UV-induced skin aging responses in fibroblasts and inhibits cell and tumor growth in models of acute myelogenous leukemia (AML).

Product Info

Cas No.

21967-41-9

Purity

≥95%

Formula

C21H18O11

Formula Wt.

446.36

IUPAC Name

(2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4, 5-trihydroxyoxane-2-carboxylic acid

Synonym

7-D-Glucuronic acid-5,6-dihydroxyflavone

Melting Point

202-205°C (lit.)

Solubility

Soluble in DMSO or ethanol.

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B0133 MSDS PDF

Info Sheet

B0133 Info Sheet PDF

References

Ding Y, Dou J, Teng Z, et al. Antiviral activity of baicalin against influenza A (H1N1/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase. Arch Virol. 2014 Jul 31. [Epub ahead of print]. PMID: 25078390.

Min W, Liu X, Qian Q, et al. The effects of baicalin against UVA-induced photoaging in skin fibroblasts. Am J Chin Med. 2014;42(3):709-27. PMID: 24871661.

Zhang L, Pu Z, Wang J, et al. Baicalin inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via the AKT/HIF-1α/p27-associated pathway. Int J Mol Sci. 2014 May 9;15(5):8153-68. PMID: 24821539.

Zhou QB, Jin YL, Jia Q, et al. Baicalin attenuates brain edema in a rat model of intracerebral hemorrhage. Inflammation. 2014 Feb;37(1):107-15. PMID: 23974988.

Zheng J, Hu JD, Huang Y, et al. Effects of baicalin on HL-60 cell xenografts in nude mice and its mechanism. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Oct;20(5):1066-71. PMID: 23114120.

Tarragó T, Kichik N, Claasen B, et al. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg Med Chem. 2008 Aug 1;16(15):7516-24. PMID: 18650094.

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