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ATB 346

Product ID A7604
Cas No. 1226895-20-0
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $70.60 In stock
5 mg $147.20 In stock
25 mg $412.00 In stock
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  • Description
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Description

ATB346 is a hydrogen sulfide-releasing non-steroidal anti-inflammatory drug (NSAID) that inhibits COX and suppresses prostaglandin production. ATB346 exhibits anti-inflammatory, analgesic, antinociceptive, immunomodulatory, and neuroprotective activities. In vivo, this compound attenuates zymosan-induced inflammation, nociception, and immune signaling. ATB346 also prevents ligature-induced periodontal bone loss and pathologies, potentially by suppressing increases in pro-inflammatory cytokine levels. Additionally, ATB346 decreases edema and improves neurological function in animal models of traumatic brain injury (TBI). ATB346 is a hydrogen sulfide releasing derivative of naproxen.

Product Info

Cas No.

1226895-20-0

Purity

≥99%

Formula

C21H19NO3S

Formula Wt.

365.45

IUPAC Name

4-Carbamothioylphenyl 2-(6-methoxy-2-naphthyl)propanoate

Synonym

ATB-346

Solubility

DMSO: ≥ 52 mg/mL

Appearance

Light yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A7604 MSDS PDF

Info Sheet

A7604 Info Sheet PDF

References

Dief AE, Mostafa DK, Sharara GM, et al. Hydrogen sulfide releasing naproxen offers better anti-inflammatory and chondroprotective effect relative to naproxen in a rat model of zymosan induced arthritis. Eur Rev Med Pharmacol Sci. 2015 Apr;19(8):1537-46. PMID: 25967731.

Herrera BS, Coimbra LS, da Silva AR, et al. The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis. Med Gas Res. 2015 Feb 27;5:4. PMID: 25755876.

Campolo M, Esposito E, Ahmad A, et al. Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice. J Neuroinflammation. 2014 Dec 4;11:196. PMID: 25472548.

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