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Nimustine Hydrochloride

Nimustine Hydrochloride

Product ID N3452
Cas No. 55661-38-6
Purity ≥97%
Product Unit SizeCostQuantityStock
100 mg $61.10 In stock
500 mg $102.00 In stock
1 g $139.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nimustine is a nitrosourea compound that exhibits anticancer chemotherapeutic activity. Nimustine induces DNA cross-linking and double-stranded DNA breaks. This compound is clinically used to treat gliomas and may also downregulate expression of DNA ligase IV.

Product Info

Cas No.

55661-38-6

Purity

≥97%

Formula

C9H13ClN6O2 • HCl

Formula Wt.

309.16

Chemical Name

N'-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(2- chloroethyl)-N-nitrosourea hydrochloride

IUPAC Name

3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1- nitrosourea;hydrochloride

Synonym

ACNU, Nidran  

Melting Point

170-171°C

Solubility

Soluble in methanol and n-butanol. Soluble in water (100 mM) and DMSO (75 mM). (Practically insoluble in ethyl acetate, ether, chloroform and benzene.

Appearance

White or Slightly Yellow Crystalline Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

N3452 MSDS PDF

Info Sheet

N3452 Info Sheet PDF

References

Kondo N, Takahashi A, Mori E, et al. DNA ligase IV is a potential molecular target in ACNU sensitivity. Cancer Sci. 2010 Aug;101(8):1881-5. PMID: 20487264.

Kanamaru R, Asamura M, Sato H, et al. Studies on the mechanism of action of ACNU, 1-(4-amino-2-methylpyrimidine-5-yl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride: effects on cultured HeLa S3 cells. Tohoku J Exp Med. 1980 Dec;132(4):431-41. PMID: 6942530.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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