LKT Labs

Biochemicals for Life Science Research

Pimecrolimus

Pimecrolimus

Product ID P3348
Cas No. 137071-32-0
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $60.10 In stock
5 mg $112.60 In stock
25 mg $375.60 In stock
Bulk Quote

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Description

Pimecrolimus is a calcineurin inhibitor that exhibits immunosuppressive, anti-inflammatory, and antinociceptive activities. Pimecrolimus prevents calcineurin from dephosphorylating nuclear factor of activated T cells (NF-AT), inhibiting T cell signaling; this inhibition of T cell signaling also prevents release of pro-inflammatory cytokines. Pimecrolimus is clinically used to treat inflammatory skin diseases such as cutaneous lupus erythematosus and contact dermatitis. This compound also displays some antinociceptive properties and may desensitize transient receptor potential vanilloid receptor 1 (TRPV1) channels in skin sensory neurons.

Product Info

Cas No.

137071-32-0
Purity

≥99%
Formula

C43H66ClNO11
Formula Wt.

810.45
Chemical Name

33-epi-chloro-33-desoxyascomycin
IUPAC Name

(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-[(E)-1-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]prop-1-en-2-yl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
Synonym

33-epi-chloro-33-desoxyascomycin; Elidel; SDZ-ASM 981; SDZ ASM 981; SDZ-ASM-981; Picrolimus; ASM981; ASM-981; ASM 981
Solubility

Soluble in DMSO (25 mg/mL). Soluble in ethanol (25 mg/mL). Soluble in chloroform, methanol.
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P3348 MSDS PDF
Info Sheet

P3348 Info Sheet PDF

References

Xie ZQ, Lan YZ. Effectiveness of pimecrolimus cream for women patients with sensitive skin and its underlying mechanism. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Aug;34(4):375-8. PMID: 22954121.

Lampropoulos CE, D'Cruz DP. Topical calcineurin inhibitors in systemic lupus erythematosus. Ther Clin Risk Manag. 2010 Apr 15;6:95-101. PMID: 20421909.

Hultsch T, Kapp A, Spergel J. Immunomodulation and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis. Dermatology. 2005;211(2):174-87. Review. Erratum in: Dermatology. 2005;211(3):292. PMID: 16088174.

Lipozencić J. Pimecrolimus--a safe and effective local immunomodulator in the treatment of inflammatory skin diseases. Acta Dermatovenerol Croat. 2005;13(1):63-9. PMID: 15788149.

Gupta AK, Chow M. Pimecrolimus: a review. J Eur Acad Dermatol Venereol. 2003 Sep;17(5):493-503. PMID: 12941081.

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