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Parecoxib is a prodrug of valdecoxib and non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory and analgesic activities. Parecoxib inhibits COX-2 and prevents neuropathic pain-induced hypersensitivity in animal models of chronic constrictive injury.
| Cas No. | 198470-85-8 |
|---|---|
| Purity | ≥99% |
| Formula | C19H18N2O4SNa |
| Formula Wt. | 392.40 |
| IUPAC Name | sodium;[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl-propanoylazanide |
| Solubility | Soluble in DMSO |
| Appearance | White to off white powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhou GB, Li HY, Ji JQ, et al. Analgesic effect of COX inhibitors and its mechanism in a rat model of neuropathic pain. Nan Fang Yi Ke Da Xue Xue Bao. 2011 Oct;31(10):1764-6. PMID: 22027786.
Koppert W, Wehrfritz A, Körber N, et al. The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans. Pain. 2004 Mar;108(1-2):148-53. PMID: 15109518.