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Ursodeoxycholic Acid

Ursodeoxycholic Acid

Product ID U6873
Cas No. 128-13-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $60.10 In stock
5 g $180.30 In stock
25 g $375.60 In stock
Bulk Quote

Quicklinks

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  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ursodeoxycholic acid is an endogenous secondary bile acid produced by bacterial metabolism of bile acids in the intestines. Ursodeoxycholic acid decreases cholesterol absorption, dissolves gallstones, and treats cirrhosis and other liver diseases. This compound exhibits immunosuppressive, antioxidative, hepatoprotective, anticancer, and gastrointestinal motility modulating activities. In animal models, ursodeoxycholic acid decreases spleenocyte proliferation and levels of IL-2, L-6, and IFN-γ, increases levels of IL-10, and prevents allograft rejection. In other animal models, this compound increases levels of glutathione and decreases levels of malondialdehyde, myeloperoxidase, and ROS. In colon cancer cells, ursodeoxycholic acid inhibits cellular proliferation and induces apoptosis; similarly, it also induces differentiation, senescence, and HDAC6-dependent hypoacetylation. In other cancer models, this compound inhibits telomerase and may exhibit chemopreventive potential. In vivo, ursodeoxycholic acid decreases gastrointestinal transit time and increases gastric emptying rates.

Product Info

Cas No.

128-13-2

Purity

≥98%

Formula

C24H40O4

Formula Wt.

392.57

Chemical Name

(3α,5β,7β)-3,7-Dihydroxycholan-24-oic acid

IUPAC Name

(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2, 3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

Synonym

Ursodiol, Actigall, Delursan, Desol, Litursol, Peptarom, Urdes, Ursofalk, Ursolvan

Melting Point

203°C

Solubility

Insoluble in water. Soluble in ethanol. Slightly soluble in chloroform. Soluble in DMSO (>100 mg/mL).

Appearance

White Fine Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

U6873 MSDS PDF

Info Sheet

U6873 Info Sheet PDF

References

Zhang Q, Nakaki T, Iwami D, et al. Induction of regulatory T cells and indefinite survival of fully allogeneic cardiac grafts by ursodeoxycholic acid in mice. Transplantation. 2009 Dec 27;88(12):1360-70. PMID: 20029332.

El-Sherbiny GA, Taye A, Abdel-Raheem IT. Role of ursodeoxycholic acid in prevention of hepatotoxicity caused by amoxicillin-clavulanic acid in rats. Ann Hepatol. 2009 Apr-Jun;8(2):134-40. PMID: 19502657.

Akare S, Jean-Louis S, Chen W, et al. Ursodeoxycholic acid modulates histone acetylation and induces differentiation and senescence. Int J Cancer. 2006 Dec 15;119(12):2958-69. PMID: 17019713.

Colecchia A, Mazzella G, Sandri L, et al. Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients. World J Gastroenterol. 2006 Sep 7;12(33):5336-43. PMID: 16981264.

Custom Order

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