• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Endothelin-1, human

Endothelin-1, human

Product ID E5219
Cas No. 117399-94-7
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $204.40 In stock
1 mg $272.60 In stock
2.5 mg $613.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Endothelin-1 is an endogenous peptide agonist at endothelin A and B (ET-A/B) receptors that exhibits anti-angiogenic and vasoconstrictive activities. Endothelin-1 decreases tube formation and PPARγ expression in pulmonary artery endothelial cells. This peptide also increases expression of IL-18 in osteoblasts, inducing proliferation.

Product Info

Cas No.

117399-94-7

Purity

≥95%

Formula

C109H159N25O32S5

Formula Wt.

2491.95

Synonym

ET-1.

Solubility

Soluble in 1% acetic acid (1 mg/mL), water (1 mg/mL), 50% acetonitrile (1 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E5219 MSDS PDF

Info Sheet

E5219 Info Sheet PDF

References

Zhong X, Wang H, Huang S. Endothelin-1 induces interleukin-18 expression in human osteoblasts. Arch Oral Biol. 2014 Mar;59(3):289-96. PMID: 24581851.

Osmond JM, Gonzalez Bosc LV, Walker BR, et al. Endothelin-1-induced vasoconstriction does not require intracellular Ca2+ waves in arteries from rats exposed to intermittent hypoxia. Am J Physiol Heart Circ Physiol. 2014 Mar;306(5):H667-73. PMID: 24414066.

Wolf D, Tseng N, Seedorf G, et al. Endothelin-1 decreases endothelial PPARγ signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(4):L361-71. PMID: 24337925.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P0049

    Pamidronate Disodium Pentahydrate

    Bisphosphonate.

    ≥98%
  • R3586

    Rivastigmine Tartrate

    AChE and BChE inhibitor.

    ≥99%
  • F465818

    Fluorouracil Impurity B

    Fluorouracil impurity

    ≥95%
  • A7200

    AS-252424

    p110γ PI3K inhibitor, potential TRPC1/5/6 nega...

    ≥98%
  • G823720

    Gusacitinib

    SYK/JAK inhibitor

    ≥98%
  • L1340

    LDK378

    ALK and IGF-1R inhibitor.

    ≥99%
  • G7232

    GS-9973

    Syk inhibitor.

    ≥98%
  • C0221

    Caffeine

    Xanthine alkaloid found in coffee, tea, and oth...

    ≥98%
  • T0106

    Xylosyltaxol

    Taxane found in species of Taxus; potential mic...

    ≥98%
  • T2816

    L-Theanine

    Non-essential amino acid found in Camellia and ...

    ≥98%
  • F465817

    Flunisolide

    Corticosteroid

    ≥90%
  • A4802

    Amantadine Hydrochloride

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • M1877

    Methylprednisolone

    Synthetic steroid; glucocorticoid agonist.

    ≥96%
  • C1648

    α-Cembrenediol

    Diterpene found in Anisomeles.

    ≥99%
  • P2817

    Phentolamine Hydrochloride

    ATP-sensitive K+ channel activator, α-adrenerg...

    ≥98%
  • C1876

    Cetirizine Dihydrochloride

    Histamine H1 antagonist.

    ≥99%
  • N8460

    NVP-BHG712

    EphB4 inhibitor.

    ≥98%
  • D5611

    Docosahexaenoic Acid (all cis-4,7,10,13,16,19) Methyl Ester

    Essential fatty acid found in fish oil, involve...

    ≥99%
  • P1200

    PD-184352

    MEK1/2 and Raf inhibitor.

    ≥98%
  • D183736

    19-O-Desmethoxy rapamycin

    Fermentation impurity

    ≥94%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only