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AS-252424 is an inhibitor of p110γ PI3K that exhibits anti-inflammatory activity. In animal models of peritoneal inflammation, AS-252424 decreases leukocyte recruitment. In vascular smooth muscle cells, AS-252424 decreases endothelin A receptor-mediated activity of transient receptor potential canonical 1/5/6 channels (TRPC1/5/6) and potentiates related activity of TRPC3/7 channels.
| Cas No. | 900515-16-4 |
|---|---|
| Purity | ≥98% |
| Formula | C14H8FNO4S |
| Formula Wt. | 305.28 |
| IUPAC Name | (5E)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione |
| Solubility | DMSO 61 mg/mL (199.81 mM) Water Insoluble Ethanol Insoluble |
| Appearance | Yellow Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Shi J, Ju M, Large WA, et al. Pharmacological profile of phosphatidylinositol 3-kinases and related phosphatidylinositols mediating endothelin(A) receptor-operated native TRPC channels in rabbit coronary artery myocytes. Br J Pharmacol. 2012 Aug;166(7):2161-75. PMID: 22404177.
Pomel V, Klicic J, Covini D, et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J Med Chem. 2006 Jun 29;49(13):3857-71. PMID: 16789742.
