Katacalcin

Name: Katacalcin
SKU: K0276
Availability: InStock

Product ID K0276

Cas No. 85916-47-8

Purity ≥95%

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Description
Product Info
Shipping and Storage
Downloads
References

Description

Katacalcin is a polypeptide encoded by the calc-1 gene that is also known as crustacean cardioactive peptide (CCAP or CCP1). Katacalcin exhibits immunomodulatory activity. Katacalcin activates PKA and decreases intracellular Ca2+ levels, inducing migration of CD14+ peripheral blood mononuclear cells and deactivating chemotaxis. Katacalcin may be used as a biomarker for medullary thyroid tumors. Additionally, this peptide may play a role in signaling cascade elicited by treatments for mood disorders, such as antipsychotic medications.

Product Info

Cas No.	85916-47-8
Purity	≥95%
Formula	C₉₇H₁₅₄N₃₄O₃₆S₂
Formula Wt.	2436.64
Synonym	CCAP, CCP I, Calcitonin carboxyl-terminal flanking peptide
Solubility	Soluble in DMSO.
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	K0276 MSDS PDF
Info Sheet	K0276 Info Sheet PDF

References

Kaneider NC, Egger P, Wiedermann FJ, et al. Involvement of cyclic adenosine monophosphate-dependent protein kinase A and pertussis toxin-sensitive G proteins in the migratory response of human CD14+ mononuclear cells to katacalcin. J Bone Miner Res. 2002 Oct;17(10):1872-82. PMID: 12369791.

Angelucci F, Gruber SH, Mathé AA. A pilot study of rat brain regional distribution of calcitonin, katacalcin and calcitonin gene-related peptide before and after antipsychotic treatment. Neuropeptides. 2001 Oct-Dec;35(5-6):285-91. PMID: 12030813.

Blind E, Raue F, Klaiber T, et al. Evaluation of sensitive PDN-21 (katacalcin) determination as tumor marker in medullary thyroid carcinoma. J Endocrinol Invest. 1992 Feb;15(2):93-8. PMID: 1569295.