LKT Labs

Biochemicals for Life Science Research

Azelastine Hydrochloride

Product ID A9818
Cas No. 79307-93-0
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $104.00 In stock
500 mg $294.70 In stock
1 g $467.90 In stock
Bulk Quote

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Description

Azelastine is a second generation antihistamine that inhibits H1 histamine receptors. Azelastine exhibits anti-allergic, anti-inflammatory, and anti-tussive activities and is clinically used to treat allergic rhinitis. Azelastine activates transient receptor potential vanilloid 1 (TRPV1) channels, inducing desensitization. In mast cells, azelastine inhibits production of TNF-α, IL-6, and IL-8 and suppresses activation of NF-κB. Additionally, this compound decreases capsaicin-induced cough in vivo.

Product Info

Cas No.

79307-93-0
Purity

≥98%
Formula

C22H23N3O • HCl
Formula Wt.

418.35
Chemical Name

4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl- 1H-azepin-4-yl)-1(2H)-phthalazinone hydrochloroide
IUPAC Name

4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one; hydrochloride
Synonym

Allergodil, Astelin, Azeptin, Optilast, Rhinolast
Melting Point

225-229°C
Solubility

Slightly soluble in ethanol, octanol or glycerine.

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A9818 MSDS PDF
Info Sheet

A9818 Info Sheet PDF

References

Singh U, Bernstein JA, Haar L, et al. Azelastine desensitization of transient receptor potential vanilloid 1: A potential mechanism explaining its therapeutic effect in nonallergic rhinitis. Am J Rhinol Allergy. 2014 May;28(3):215-24. PMID: 24980233.

Horak F, Zieglmayer UP. Azelastine nasal spray for the treatment of allergic and nonallergic rhinitis. Expert Rev Clin Immunol. 2009 Nov;5(6):659-69. PMID: 20477689.

Kempuraj D, Huang M, Kandere-Grzybowska K, et al. Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells. Int Arch Allergy Immunol. 2003 Nov;132(3):231-9. PMID: 14646384.

Ito N, Shioya T, Watanabe A, et al. Mechanism of the antitussive effect of azelastine in guinea pigs. Arzneimittelforschung. 2002;52(6):441-7. PMID: 12109044.

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