Indoximod is an inhibitor of indoleamine 2,3 dioxygenase, which plays a role in immune regulation. Indoximod has been found to enhance inflammatory cytokines IL-1beta and IL-6 expression in human corneal epithelial cells exposed to inactivated A. fumigatus spores. Indoximod has also been found as a metabolite in tomato plants exposed to fungi or bacteria.
| Cas No. | 110117-83-4 |
|---|---|
| Purity | ≥98% |
| Formula | C12H14N2O2 |
| Formula Wt. | 218.26 |
| Synonym | NLG-8189, 1-Methyl-D-tryptophan, |
| Solubility | DMSO:1 mg/mL warmed (4.58 mM) Water:Insoluble Ethanol:Insoluble |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Soliman HH, Minton SE, Han HS, et al. A phase I study of indoximod in patients with advanced malignancies. Oncotarget. 2016 Apr 19;7(16):22928-22938. PMID: 27008709
Jiang N, Zhao G, Lin J, et al. Indoleamine 2,3-dioxygenase is involved in the inflammation response of corneal epithelial cells to aspergillus fumigatus infections. PLoS One. 2015 Sep 11;10(9):e0137423. PMID: 26361229
Camanes G, Scalschi L, Vicedo B, et al. An untargeted global metabolomic analysis reveals the biochemical changes underlying basal resistance and priming in Solanum lycopersicum, and identifies 1-methyltryptophan as a metabolite involved in plant responses to Botrytis cinerea and Pseudomonas syringae. Plant J. 2015 Oct;84(1):125-139. PMID: 26270176
