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GS-4997 is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1). ASK1 is an important mediator of oxidative stress effects. It has shown efficacy in the treatment of cancer cell lines exhibiting overexpression of ABC transporters. It is also being evaluated as areatment for non-alcoholic steatohepatitis (NASH).
| Cas No. | 1448428-04-3 |
|---|---|
| Purity | ≥99% |
| Formula | C24H24FN7O |
| Formula Wt. | 445.5 |
| IUPAC Name | 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-[6-(4-isopropyl-4H-1,2,4-triazol-3-yl)-2-pyridinyl]-4-methylbenzamide |
| Synonym | GS 4997, GS4997, Selonsertib |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ji N., Yang Y., et al. Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. Cancer Lett. 440-441:82-93 (2019). PMID: 30315846.
Mukherjee S., Zhelnin L., et al. Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype. Am J Transl Res. 11(3):1531-40 (2019). PMID: 30972180.