LKT Labs

Biochemicals for Life Science Research

Progesterone

Product ID P6854
Cas No. 57-83-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $39.30 In stock
25 g $114.60 In stock
100 g $415.30 In stock
Bulk Quote

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Description

Progesterone is an endogenous steroid hormone that activates progesterone receptors (PRs) and inhibits mineralocorticoid receptors (MRs), nicotinic acetylcholine receptors (nAChRs), and σ1/2 receptors. Progesterone exhibits neuroprotective activity, inducing myelin sheath formation and supporting neurotransmission. Progesterone also plays a significant role in reproduction and mammary gland development. Clinically, this compound is used to prevent preterm birth and is occasionally used in hormone replacement therapy (HRT).

Product Info

Cas No.

57-83-0
Purity

≥98%
Formula

C21H30O2
Formula Wt.

314.47
Chemical Name

Pregn-4-ene-3,20-dione
IUPAC Name

(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14, 15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Synonym

Corlutin, Gesterol, Luteol, Prolutone, Prolidon, Syngesterone, Utrogestan
Melting Point

128-132°C
Solubility

Insoluble in water. Soluble in alcohol, acetone or dioxane.
Appearance

White or almost white crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P6854 MSDS PDF
Info Sheet

P6854 Info Sheet PDF

References

Johannessen M, Fontanilla D, Mavlyutov T, et al. Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels. Am J Physiol Cell Physiol. 2011 Feb;300(2):C328-37. Erratum in: Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C997. PMID: 21084640.

da Fonseca EB, Bittar RE, Carvalho MH, et al. Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. Am J Obstet Gynecol. 2003 Feb;188(2):419-24. PMID: 12592250.

Baulieu E, Schumacher M. Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination. Steroids. 2000 Oct-Nov;65(10-11):605-12. PMID: 11108866.

Rupprecht R, Reul JM, van Steensel B, et al. Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur J Pharmacol. 1993 Oct 15;247(2):145-54. PMID: 8282004.

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