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Methyldopa Sesquihydrate

Product ID M1779
Cas No. 41372-08-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $52.80 In stock
5 g $74.10 In stock
10 g $132.30 In stock
Bulk Quote

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  • Product Info
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  • Description
  • Product Info
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Description

Methyldopa exhibits antihypertensive and sedative activities. In circulation, methyldopa is metabolized to α-methylnorepinephrine by dopamine β-hydroxylase, which activates α2-adrenergic receptors, acting as a sympatholytic and inhibiting the sympathetic nervous system. This compound also inhibits DOPA decarboxylase, decreasing production of dopamine, norepinephrine, and epinephrine. In animal models, methyldopa exhibits NO-dependent sedative activity similar to that of clonidine.

Product Info

Cas No.

41372-08-1

Purity

≥98%

Formula

C10H13NO4 • 3/2H2O

Formula Wt.

238.24

Chemical Name

3-Hydroxy-α-methyl-L-tyrosine sesquihydrate

IUPAC Name

(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate

Synonym

Methyl-L-DOPA, MK-351, Hyperax

Melting Point

>300°C (dec.)

Solubility

Soluble in dilute mineral acids and water (10mg/mL, pH 5.0). Insoluble in organic solvents.

Appearance

White or yellowish white, crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M1779 MSDS PDF

Info Sheet

M1779 Info Sheet PDF

References

Sucak A, Kanat-Pektas M, Gungor T, et al. Leptin levels and antihypertensive treatment in preeclampsia. Singapore Med J. 2010 Jan;51(1):39-43. PMID: 20200774.

Soares de Moura R, Rios AA, et al. The effects of nitric oxide synthase inhibitors on the sedative effect of clonidine. Anesth Analg. 2001 Nov;93(5):1217-21. PMID: 11682401.

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