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DAPT

Product ID D0260
Cas No. 208255-80-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $61.50 In stock
5 mg $107.00 In stock
25 mg $382.70 In stock
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  • Product Info
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  • Description
  • Product Info
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  • Downloads
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Description

DAPT is a γ-secretase inhibitor that suppresses Notch signaling and exhibits neuroprotective and anticancer activities. DAPT inhibits proliferation of cancer stem cells. It also promotes differentiation of neural stem cells into neurons with Lingo-1 shRNA as a possible treatment for spinal cord injury.

Product Info

Cas No.

208255-80-5

Purity

≥98%

Formula

C23H26F2N2O4

Formula Wt.

432.47

IUPAC Name

2-Methyl-2-propanyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetate

Synonym

GSI-IX

Solubility

DMSO: ≥ 215 mg/mL

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D0260 MSDS PDF

Info Sheet

D0260 Info Sheet PDF

References

Liu J, Mao Z, Huang J, et al. Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy. Biochem Biophys Res Commun. 2014 Feb 21;444(4):670-5. PMID: 24502949.

Wang J., Ye Z., et al. Lingo-1 shRNA and Notch signaling inhibitor DAPT promote differentiation of neural stem/progenitor cells into neurons. Brain Res. 1634:34-44 (2016). PMID: 26607252.

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