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NVP-BGT226

Product ID N8604
Cas No. 1245537-68-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $140.60 In stock
5 mg $413.30 In stock
10 mg $661.50 Please Inquire
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  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

NVP-BGT226 is an inhibitor of PI3K and mTORC1/2. An intracellular Leishmania parasite assay found it to be even more potent than amphotericin B or miltefosine. In a mouse model of T. brucei acute infection, NVP-BGT226 showed slightly improved effiecacy compared to Torin2.

Product Info

Cas No.

1245537-68-1

Purity

≥98%

Formula

C32H29F3N6O6

Formula Wt.

650.60

IUPAC Name

(Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]imidazo[4,5-c]quinolin-2-one

Synonym

BGT226

Solubility

DMSO 30 mg/mL (46.11 mM) Water Insoluble Ethanol Insoluble

Appearance

Off-white Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N8604 MSDS PDF

Info Sheet

N8604 Info Sheet PDF

References

Phan TN, Baek KH, Lee N, et al. In vitro and in vivo activity of mTOR kinase and PI3K inhibitors against Leishmania donovani and Trypanosoma brucei. Molecules. 2020 Apr 23;25(8):1980. PMID: 32340370.

Hassett M, Sternberg A, Roepe P. Inhibition of human class I vs class III phosphatidylinositol 3’-kinases. Biochemistry. 2017 Aug 22;56(33):4326-4334. PMID: 28719179.

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