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CFI-400945 is an inhibitor of polo-like kinase 4 (PLK4). PLK4 plays an important role in centriole replication, and inhibition of PLK4 disrupts mitosis. CFI-400945 inhibits tumor growth in models of pancreatic cancer. PLK4 inhibition may be effective against osteosarcoma, where it is theorized that overexpression of PLK4 may be a driving force in osteosarcoma development and preservation.
| Cas No. | 1338806-73-7 |
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| Purity | ≥98% |
| Formula | C33H34N4O3 |
| Formula Wt. | 534.66 |
| Chemical Name | (1R,2S)-2-{3-[(E)-2-(4-{[(2R,6S)-2,6-Dimethyl-4-morpholinyl]methyl}phenyl)vinyl]-1H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one |
| IUPAC Name | (1R,2S)-2-{3-[(E)-2-(4-{[(2R,6S)-2,6-Dimethyl-4-morpholinyl]methyl}phenyl)vinyl]-1H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one |
| Synonym | CFI 400945, CFI400945, CFI-400945 (free base) |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Lohse I., Mason J., et al. Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts. Oncotarget. 8(2):3064-71 (2017). PMID: 27902970.
Kelleher F., Kores J., et al. Targeting the centrosome and polo-like kinase 4 in osteosarcoma. Carcinogenesis. 40(4):493-99 (2019). PMID: 30508038.