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Nimodipine

Nimodipine

Product ID N3448
Cas No. 66085-59-4
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $49.70 In stock
500 mg $126.80 In stock
1 g $220.50 In stock
5 g $529.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nimodipine is an antagonist at L-type Ca2+ channels that exhibits antihypertensive, neuroprotective, neuromodulatory, cognition enhancing, and anti-inflammatory activities. In animal models of subarachnoid hemorrhage, nimodipine prevents cerebral ischemia and vasospasm. Nimodipine also inhibits methylmercury-induced behavioral neurotoxicity in vivo. In animal models of Alzheimer’s disease, nimodipine inhibits amyloid-β (Aβ)-stimulated release of IL-1β and resulting neurotoxicity. This compound also inhibits neurological symptoms of drug-induced withdrawal, suppressing anxiety, depression, and memory impairment.

Product Info

Cas No.

66085-59-4

Purity

≥98%

Formula

C21H26N2O7

Formula Wt.

418.44

Chemical Name

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylic acid 2-methoxyethyl 1-methyl- ethyl ester

IUPAC Name

3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Synonym

Periplum, Nimotop

Melting Point

125°C

Solubility

Soluble in methanol or DMSO. Insoluble in water.

Appearance

Light yellow crystalline powder

Shipping and Storage

Store Temp

ambient

Ship Temp

Ambient

Downloads

MSDS

N3448 MSDS PDF

Info Sheet

N3448 Info Sheet PDF

References

Bia A GY, Polak P, Michalak A, et al. Influence of calcium channel antagonists on nonsomatic signs of nicotine and d-amphetamine withdrawal in mice. Pharmacol Rep. 2014 Apr;66(2):212-22. PMID: 24911072.

Bailey JM, Hutsell BA, Newland MC. Dietary nimodipine delays the onset of methylmercury neurotoxicity in mice. Neurotoxicology. 2013 Jul;37:108-17. PMID: 23583802.

Sanz JM, Chiozzi P, Colaianna M, et al. Nimodipine inhibits IL-1β release stimulated by amyloid β from microglia. Br J Pharmacol. 2012 Dec;167(8):1702-11. PMID: 22831460.

Sharma N, Cho DH, Kim SY, et al. Magnesium sulfate suppresses L-type calcium currents on the basilar artery smooth muscle cells in rabbits. Neurol Res. 2012 Apr;34(3):291-6. PMID: 22450340.

Janjua N, Mayer SA. Cerebral vasospasm after subarachnoid hemorrhage. Curr Opin Crit Care. 2003 Apr;9(2):113-9. PMID: 12657973.

Custom Order

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